Caring for patients with a prosthetic eye can be a challenge to clinicians. Regardless of the circumstances leading to eye removal, inspection of the underlying tissue should be part of a comprehensive eye exam. Maintaining the overall health of the anophthalmic socket is critical in patient comfort and optimal prosthetic fit. Discussions will focus on anophthalmic proce-dures and preparation of the socket for prosthetic fitting. Care and man-agement of the prosthesis and the anophthalmic socket, including associ-ated ocular tissue disorders will be emphasized. The article will enhance the clinician’s comfort level managing patients wearing ocular prosthesis.